Quantitative signal properties from standardized MRIs correlate with multiple sclerosis disability Thursday, May 20, 2021 Objective: To enable use of clinical magnetic resonance images (MRIs) to quantify abnormalities in normal appearing (NA) white matter (WM) and gray matter (GM) in multiple sclerosis (MS) and to determine associations with MS-related disability. Identification of these abnormalities heretofore has required specialized scans not routinely available in clinical practice. Read More
In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping Thursday, May 20, 2021 A 35-year-old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient- Recalled-Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease. Read More
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions Thursday, May 20, 2021 Multiple sclerosis (MS) lesions are heterogeneous with regard to inflammation, demyelination, axonal injury, and neuronal loss. We previously developed a diffusion basis spectrum imaging (DBSI) technique to better address MS lesion heterogeneity. We hypothesized that the profiles of multiple DBSI metrics can identify lesion-defining patterns. Here we test this hypothesis by combining a deep learning algorithm using deep neural network (DNN) with DBSI and other imaging methods. Read More
Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica Thursday, May 20, 2021 Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Central vein sign (CVS) prevalence has not yet been well-established in MOGAD. The objective of this study is to characterize the magnetic resonance imaging (MRI) appearance and CVS prevalence of MOGAD patients in comparison to matched cohorts of MS and AQP4+ NMOSD. Read More
Illumination Gala Special Preview Thursday, May 13, 2021 Join us virtually on June 5 for our annual Illumination Gala to learn more about how the Cancer Frontier Fund is supporting breakthrough research at Siteman Cancer Center. Read More
T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients Tuesday, April 27, 2021 Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune demyelinating disease. Its pathogenesis involves humoral and cellular immunity, with production of pro- and anti-inflammatory cytokines by T cells. Read More
Can CSF biomarkers predict future MS disease activity and severity? Tuesday, April 27, 2021 Multiple sclerosis (MS) is a heterogeneous disease. With several disease modifying treatments of different mechanisms of action in use now and in development, it is important to identify reliable biomarkers to identify those higher risk MS patients in whom stronger but riskier treatments might be used, as well as to identify those for whom safer treatments of lower efficacy would be sufficient. Read More
The Foundation Welcomes New Board Members Friday, April 02, 2021 The Foundation is very pleased to welcome six new board members in 2021. You can read more about the first three here. Read More
Thank You Local Businesses for Your Donations to Frontline Caregivers Friday, February 26, 2021 The outpouring of support demonstrated for Barnes-Jewish Hospital caregivers on the frontline battling COVID-19 by businesses and individuals in our community has been nothing short of astounding. Read More
Scholarship Honors Homer G. Phillips Hospital Nurses Thursday, February 11, 2021 After joining Goldfarb School of Nursing at Barnes-Jewish College, Nancy Ridenour, Ph.D., APRN, FAAN, The Maxine Clark and Bob Fox President, began to search for ways to help the underserved and increase the number of Black nursing students. She found inspiration in “The Color of Medicine,” a documentary about the historic Homer G. Phillips Hospital that served the St. Louis Black community from 1937 until 1979. Read More