Availability of funding often determines the ability, success, and rate at which scientific discoveries can progress from an early idea to patient care and treatment. Gifts made to the Cancer Frontier Fund reach physician-scientists through a rigorous, peer-reviewed selection process that identifies and resources the most promising research in cancer in two cycles annually and positions those projects for successful federal funding necessary to accelerate the impact on patient care. It is critical to ensure this fund is replenished and that each generation has access to the most innovative therapies.